Bruce Charlton made a comment on a recent post of his which you can find here. (The comment is at the bottom.) He said "Metaphysics is prior to science, therefore science cannot 'inform' it." This is something I have long thought, ever since the days when there were popular books linking mysticism and quantum mechanics and the like, and there was much excitement that science was confirming the wisdom of the ancients about the nature of reality and consciousness. I thought then and I think now this was a mistake. You see, metaphysics to be truly spiritual in content must be founded on intuition and insight, direct perception. It comes from above to the below, from the spiritual. Science is just the opposite. It comes from the physical or material. Please don't tell me scientists have intuitions. That isn't the point. It's the primary level of awareness that matters, the plane of insight. The true metaphysician thinks from the metaphysical level. The scientist speaks from the physical or mental which is part of the material.
Science may, using its own language, confirm some of the insights of the metaphysical but this is of no spiritual use because it comes from below. Science might "prove" in some way that God exists but this would be spiritually meaningless and spiritually worthless. It would just create a thoughtform of God on the mental level and would have nothing to do with the real God who is spirit and must be worshipped/approached in spirit and in truth. The commenter to whom Bruce was responding said that reality is one and the divisions in knowledge are human artefacts but this is wrong. Reality may be one but the divisions in reality are real. The different levels of consciousness, at their most basic, the spiritual and material, operate in quite different ways. What operates materially, as science does, can never inform the spiritual. It can describe it in its own terms but it cannot enter into it. It remains forever outside unless it approaches it on its own terms. The lesser can never encompass the greater though the converse is true.
Science is a noble pursuit because it seeks to uncover truth. (At least, it used to. It's hard to have the same positive attitude these days and even harder post 2020.) However, it always remains outside the metaphysical because it only relates to the phenomenal world. It can approach the spiritual when rightly oriented but the scientific method is of no use when seeking to understand the spiritual in the proper sense. You can only understand the spiritual spiritually. A scientific understanding of the spiritual is by definition materialistic. You cannot comprehend music in terms of the shape of the notes even if you theorise that the notes are expressing something more than their physical form. If science really wants to get to grips with the metaphysical world it must humble itself and knows its limits. Then it might start to go beyond them but it will be transformed into something else in the process.
This is not saying science is a waste of time in terms of the pursuit of knowledge (I'm not talking about its technological applications) or a futile endeavour. It may well be that by having gone through the scientific mode of thought spiritual understanding if and when one gets to it will be richer. The mind will have been sharpened and therefore more receptive to higher truth than it might otherwise have been even if this higher truth can never be known by science as it is in itself.